Dr Marco Düring, MD, was invited on the 14th June 2017 by the SEGWAY investigators, Pr Stéphanie DEBETTE (PI), Pr Christophe TZOURIO and Pr Bernard MAZOYER.
He is the Research Group Leader “Vascular cognitive impairment”, Institute for Stroke and Dementia Research (ISD), University Hospital of Munich, Germany.
Dr. Düring’s team works on the mechanisms by which vascular dysfunction causes cognitive decline. The major focus of their work is on cerebral small vessel disease (SVD), the most common cause of vascular cognitive impairment (VCI) and also a frequent finding in patients with neurodegenerative disease including Alzheimer’s disease. Their methodological expertise is in structural and functional neuroimaging in humans using advanced analytical and statistical techniques. The team uses datasets from large cohorts including population-based samples as well as patients with stroke and genetically defined forms of SVD. A specific focus of our group is on CADASIL, an inherited form of SVD and model disease for pure VCI. A major theme is the development of biomarkers for VCI. We recently established a novel, fully automated and robust biomarker based on diffusion tensor imaging. Another focus of our work is on the interplay between vascular and neurodegenerative pathology. Thus, for example, the group recently revealed a link between subcortical infarcts and changes of cortical morphology implying a role for remote, secondary neurodegeneration in stroke and VCI.